White Coal Nation? Resource-making, identity, and hegemony in the struggle over Georgia’s hydropower development

This thesis examines the conflict over hydropower development in Georgia, with a particular focus on three mega-projects — the Enguri, Khudoni, and Nenskra hydropower plants (HPPs). I examine debates over hydropower taking place in Georgia’s spaces of public discourse. My analysis is rooted in resource geography and political ecology, and specifically their subfields of resource-making, critical hydropolitics, studies of resource nationalism, and Gramscian political ecology. The thesis draws on interviews and library research undertaken during eight months of fieldwork in Georgia during October 2018-July 2019, as well as supplementary desk research performed in July 2019-April 2021. Through a close reading of empirics from textual sources and interviews, I systematically sort through and present arguments mobilized for and against hydropower development in the Georgian national discourse. I also provide detailed background information to situate these arguments within their broader socio-political-economic context. I then analyze this discourse and its relation to broader social context using the academic literature mentioned above. In so doing, I make several key observations about the conflict over hydropower in Georgia, and about resource-making and resource conflicts more broadly. Specifically, I argue that the concept of a resource is an imaginary constructed for rhetorical purposes in an ‘economy of appearances’; that resources and national identity are mutually reinforcing imaginaries, each of which is (re)defined and contested with reference to the other; and that resource conflicts are Gramscian struggles to articulate and establish a hegemonic national vision, prosecuted by redefining the nation’s socio-natural relations. Finally, I use these conclusions to argue that geographers must pay increased attention to resource-making as a multi-step process, to the material consequences of disjunctures between resource imaginaries and the material world they describe, and to the way resources and other imaginaries are interwoven and therefore simultaneously produced and contested

The material geographies of Bitfury in Georgia: Integrating cryptoasset firms into global financial networks

Cryptocurrencies, such as Bitcoin, have garnered significant attention in scholarship and beyond. Geographical work on cryptocurrencies has focussed on how their energy demand interacts with local communities and economies. Less is said about the organization of cryptoasset firms and their associated demands. This paper illuminates the complex geographies of one such firm, Bitfury Group, to investigate the global and national forms and structures such companies take and the factors encouraging them to concentrate operations in certain areas. To investigate the latter, we adopt the case study of Bitfury’s operations in Georgia, a South-Caucasian country where its presence is significant. We adapt Haberly et al.’s analytical framework to explore Bitfury’s geographical dimensions. We highlight how cheap electricity, regulatory and taxation regimes, personal encounters and personalities, and the materialities of hardware and energy-saving technology define these geographies and illuminate how Bitfury actively curates advantageous regulatory spaces. We encourage future work exploring Blockchain and Bitcoin technologies to understand the companies involved as simultaneously material and virtual, and as centrepieces in global networks interweaving production and finance

Functional Characterization of Transcription Factor Motifs Using Cross-species Comparison across Large Evolutionary Distances

We address the problem of finding statistically significant associations between cis-regulatory motifs and functional gene sets, in order to understand the biological roles of transcription factors. We develop a computational framework for this task, whose features include a new statistical score for motif scanning, the use of different scores for predicting targets of different motifs, and new ways to deal with redundancies among significant motif–function associations. This framework is applied to the recently sequenced genome of the jewel wasp, Nasonia vitripennis, making use of the existing knowledge of motifs and gene annotations in another insect genome, that of the fruitfly. The framework uses cross-species comparison to improve the specificity of its predictions, and does so without relying upon non-coding sequence alignment. It is therefore well suited for comparative genomics across large evolutionary divergences, where existing alignment-based methods are not applicable. We also apply the framework to find motifs associated with socially regulated gene sets in the honeybee, Apis mellifera, using comparisons with Nasonia, a solitary species, to identify honeybee-specific associations

Adalimumab, etanercept and ustekinumab for treating plaque psoriasis in children and young people: systematic review and economic evaluation

Background: Psoriasis is a chronic inflammatory disease that predominantly affects the skin. Adalimumab (HUMIRA®, AbbVie, Maidenhead, UK), etanercept (Enbrel®, Pfizer, New York, NY, USA) and ustekinumab (STELARA®, Janssen Biotech, Inc., Titusville, NJ, USA) are the three biological treatments currently licensed for psoriasis in children. Objective: To determine the clinical effectiveness and cost-effectiveness of adalimumab, etanercept and ustekinumab within their respective licensed indications for the treatment of plaque psoriasis in children and young people. Data sources: Searches of the literature and regulatory sources, contact with European psoriasis registries, company submissions and clinical study reports from manufacturers, and previous National Institute for Health and Care Excellence (NICE) technology appraisal documentation. Review methods: Included studies were summarised and subjected to detailed critical appraisal. A network meta-analysis incorporating adult data was developed to connect the effectiveness data in children and young people and populate a de novo decision-analytic model. The model estimated the cost-effectiveness of adalimumab, etanercept and ustekinumab compared with each other and with either methotrexate or best supportive care (BSC), depending on the position of the intervention in the management pathway. Results: Of the 2386 non-duplicate records identified, nine studies (one randomised controlled trial for each drug plus six observational studies) were included in the review of clinical effectiveness and safety. Etanercept and ustekinumab resulted in significantly greater improvements in psoriasis symptoms than placebo at 12 weeks’ follow-up. The magnitude and persistence of the effects beyond 12 weeks is less certain. Adalimumab resulted in significantly greater improvements in psoriasis symptoms than methotrexate for some but not all measures at 16 weeks. Quality-of-life benefits were inconsistent across different measures. There was limited evidence of excess short-term adverse events; however, the possibility of rare events cannot be excluded. The majority of the incremental cost-effectiveness ratios for the use of biologics in children and young people exceeded NICE’s usual threshold for cost-effectiveness and were reduced significantly only when combined assumptions that align with those made in the management of psoriasis in adults were adopted. Limitations: The clinical evidence base for short- and long-term outcomes was limited in terms of total participant numbers, length of follow-up and the absence of young children. Conclusions: The paucity of clinical and economic evidence to inform the cost-effectiveness of biological treatments in children and young people imposed a number of strong assumptions and uncertainties. Health-related quality-of-life (HRQoL) gains associated with treatment and the number of hospitalisations in children and young people are areas of considerable uncertainty. The findings suggest that biological treatments may not be cost-effective for the management of psoriasis in children and young people at a willingness-to-pay threshold of £30,000 per quality-adjusted life-year, unless a number of strong assumptions about HRQoL and the costs of BSC are combined. Registry data on biological treatments would help determine safety, patterns of treatment switching, impact on comorbidities and long-term withdrawal rates. Further research is also needed into the resource use and costs associated with BSC. Adequately powered randomised controlled trials (including comparisons against placebo) could substantially reduce the uncertainty surrounding the effectiveness of biological treatments in biologic-experienced populations of children and young people, particularly in younger children. Such trials should establish the impact of biological therapies on HRQoL in this population, ideally by collecting direct estimates of EuroQol-5 Dimensions for Youth (EQ-5D-Y) utilities. Study registration: This study is registered as PROSPERO CRD42016039494. Funding: The National Institute for Health Research Health Technology Assessment programme

A realist analysis of hospital patient safety in Wales:Applied learning for alternative contexts from a multisite case study

Background: Hospital patient safety is a major social problem. In the UK, policy responses focus on the introduction of improvement programmes that seek to implement evidence-based clinical practices using the Model for Improvement, Plan-Do-Study-Act cycle. Empirical evidence that the outcomes of such programmes vary across hospitals demonstrates that the context of their implementation matters. However, the relationships between features of context and the implementation of safety programmes are both undertheorised and poorly understood in empirical terms. Objectives: This study is designed to address gaps in conceptual, methodological and empirical knowledge about the influence of context on the local implementation of patient safety programmes. Design: We used concepts from critical realism and institutional analysis to conduct a qualitative comparative-intensive case study involving 21 hospitals across all seven Welsh health boards. We focused on the local implementation of three focal interventions from the 1000 Lives+ patient safety programme: Improving Leadership for Quality Improvement, Reducing Surgical Complications and Reducing Health-care Associated Infection. Our main sources of data were 160 semistructured interviews, observation and 1700 health policy and organisational documents. These data were analysed using the realist approaches of abstraction, abduction and retroduction. Setting: Welsh Government and NHS Wales. Participants: Interviews were conducted with 160 participants including government policy leads, health managers and professionals, partner agencies with strategic oversight of patient safety, advocacy groups and academics with expertise in patient safety. Main outcome measures: Identification of the contextual factors pertinent to the local implementation of the 1000 Lives+ patient safety programme in Welsh NHS hospitals. Results: An innovative conceptual framework harnessing realist social theory and institutional theory was produced to address challenges identified within previous applications of realist inquiry in patient safety research. This involved the development and use of an explanatory intervention–context–mechanism–agency–outcome (I-CMAO) configuration to illustrate the processes behind implementation of a change programme. Our findings, illustrated by multiple nested I-CMAO configurations, show how local implementation of patient safety interventions are impacted and modified by particular aspects of context: specifically, isomorphism, by which an intervention becomes adapted to the environment in which it is implemented; institutional logics, the beliefs and values underpinning the intervention and its source, and their perceived legitimacy among different groups of health-care professionals; and the relational structure and power dynamics of the functional group, that is, those tasked with implementing the initiative. This dynamic interplay shapes and guides actions leading to the normalisation or the rejection of the patient safety programme. Conclusions: Heightened awareness of the influence of context on the local implementation of patient safety programmes is required to inform the design of such interventions and to ensure their effective implementation and operationalisation in the day-to-day practice of health-care teams. Future work is required to elaborate our conceptual model and findings in similar settings where different interventions are introduced, and in different settings where similar innovations are implemented. Funding: The National Institute for Health Research Health Services and Delivery Research programme

Toward robust image detection of crown-of-thorns starfish for autonomous population monitoring

Robust texture recognition in underwater image sequences for marine pest population control such as Crown-Of-Thorns Starfish (COTS) is a relatively unexplored area of research. Typically, humans count COTS by laboriously processing individual images taken during surveys. Being able to autonomously collect and process images of reef habitat and segment out the various marine biota holds the promise of allowing researchers to gain a greater understanding of the marine ecosystem and evaluate the impact of different environmental variables. This research applies and extends the use of Local Binary Patterns (LBP) as a method for texture-based identification of COTS from survey images. The performance and accuracy of the algorithms are evaluated on a image data set taken on the Great Barrier Reef

Wind-energy based path planning for electric unmanned aerial vehicles using Markov Decision Processes

Exploiting wind-energy is one possible way to ex- tend flight duration for Unmanned Arial Vehicles. Wind-energy can also be used to minimise energy consumption for a planned path. In this paper, we consider uncertain time-varying wind fields and plan a path through them. A Gaussian distribution is used to determine uncertainty in the Time-varying wind fields. We use Markov Decision Process to plan a path based upon the uncertainty of Gaussian distribution. Simulation results that compare the direct line of flight between start and target point and our planned path for energy consumption and time of travel are presented. The result is a robust path using the most visited cell while sampling the Gaussian distribution of the wind field in each cell

The material geographies of Bitfury in Georgia:Integrating cryptoasset firms into global financial networks

Cryptocurrencies, such as Bitcoin, have garnered significant attention in scholarship and beyond. Geographical work on cryptocurrencies has focussed on how their energy demand interacts with local communities and economies. Less is said about the organization of cryptoasset firms and their associated demands. This paper illuminates the complex geographies of one such firm, Bitfury Group, to investigate the global and national forms and structures such companies take and the factors encouraging them to concentrate operations in certain areas. To investigate the latter, we adopt the case study of Bitfury’s operations in Georgia, a South-Caucasian country where its presence is significant. We adapt Haberly et al.’s analytical framework to explore Bitfury’s geographical dimensions. We highlight how cheap electricity, regulatory and taxation regimes, personal encounters and personalities, and the materialities of hardware and energy-saving technology define these geographies and illuminate how Bitfury actively curates advantageous regulatory spaces. We encourage future work exploring Blockchain and Bitcoin technologies to understand the companies involved as simultaneously material and virtual, and as centrepieces in global networks interweaving production and finance